The Deindl group is seeking a
PhD student in Molecular Biophysics
The Deindl lab offers a stimulating multidisciplinary environment where you will work closely with experts in biophysics, biochemistry, structural and molecular biology. Our overall mission is to investigate the molecular mechanisms underlying genome-interacting processes using a highly multidisciplinary approach that combines advanced single-molecule fluorescence imaging with a range of biophysical, structural, and biochemical techniques. We are part of the SciLifeLab (https://www.scilifelab.se) and located at Uppsala University, in close proximity to beautiful Stockholm.
In the framework of an ERC Advanced Grant, the student will investigate the activity and function of disease-related genome-interacting protein complexes. A strong focus will be on developing and applying novel single-molecule FRET-based imaging approaches to record the real-time dynamics by which these protein complexes manipulate their nucleic acid substrates. Additionally, the student will leverage a powerful and as-of-yet unpublished approach, which combines single-molecule fluorescence microscopy with next-generation sequencing to enable highly multiplexed observations of complex dynamics at the single-molecule level. To uncover fundamental principles of genome organization, the student will comprehensively profile how the dynamics of genome-processing protein complexes depend on the sequence of the nucleic acids they interact with. Additionally, a range of biochemical and biophysical approaches will be employed to further characterize these processes.
Required qualifications
We are looking for a highly motivated candidate with a Master's degree or equivalent proficiency in physics, biophysics, biochemistry or similar. Excellent knowledge of English is a prerequisite, as the position is located in an international environment. We value personal characteristics such as good co-operative ability, a self-motivated personality, and a keen interest in basic research and in addressing fundamental biological questions with quantitative approaches.
Additional qualifications
Prior experience and strong interest in programming and data analysis (e.g., using MatLab and Python) are appreciated. Moreover, previous experience in single-molecule biophysics will be considered advantageous.
Starting date: as soon as possible or as otherwise agreed
Please apply through the university application portal here!
In the framework of an ERC Advanced Grant, the student will investigate the activity and function of disease-related genome-interacting protein complexes. A strong focus will be on developing and applying novel single-molecule FRET-based imaging approaches to record the real-time dynamics by which these protein complexes manipulate their nucleic acid substrates. Additionally, the student will leverage a powerful and as-of-yet unpublished approach, which combines single-molecule fluorescence microscopy with next-generation sequencing to enable highly multiplexed observations of complex dynamics at the single-molecule level. To uncover fundamental principles of genome organization, the student will comprehensively profile how the dynamics of genome-processing protein complexes depend on the sequence of the nucleic acids they interact with. Additionally, a range of biochemical and biophysical approaches will be employed to further characterize these processes.
Required qualifications
We are looking for a highly motivated candidate with a Master's degree or equivalent proficiency in physics, biophysics, biochemistry or similar. Excellent knowledge of English is a prerequisite, as the position is located in an international environment. We value personal characteristics such as good co-operative ability, a self-motivated personality, and a keen interest in basic research and in addressing fundamental biological questions with quantitative approaches.
Additional qualifications
Prior experience and strong interest in programming and data analysis (e.g., using MatLab and Python) are appreciated. Moreover, previous experience in single-molecule biophysics will be considered advantageous.
Starting date: as soon as possible or as otherwise agreed
Please apply through the university application portal here!
The Deindl group is seeking a
Two-year postdoctoral fellowship in Molecular Biophysics
The Deindl group focuses on investigating the molecular mechanisms of protein machines in the regulation of gene expression using a highly multidisciplinary approach that combines single-molecule imaging with structural and biochemical approaches. We are part of the SciLifeLab (https://www.scilifelab.se) and located at Uppsala University, in close proximity to beautiful Stockholm.
You will join our efforts, in the framework of an ERC Advanced Grant, to develop a new multiplexed method for the real-time visualization of the complex dynamics with which nucleic acid-interacting proteins interact with DNA or RNA molecules, as a function of their nucleotide sequence. This method enables a comprehensive profiling of the sequence dependence in fundamental genome-interacting processes.
We offer you to become part of a dynamic group and a stimulating multidisciplinary environment where you will closely interact with experts in biophysics, microscopy, biochemistry, and molecular biology.
Required qualifications
A PhD in biochemistry, biophysics, physics, bioinformatics, or another relevant discipline is required. To qualify for the fellowship stipend, you must have obtained your PhD no earlier than 6 years ago. Furthermore, you should have experience with next-generation sequencing, bioinformatics, and programming. Prior experience with machine learning-based data analysis is advantageous. You should be self-motivated, creative, and have an interest in basic research and method development. As the project requires collaboration with other researchers, you should have good social skills and an excellent ability to communicate in English.
The application should be written in English and include:
1. Short letter of motivation with a short description of your research interests, and why you feel you are a good match for the project.
2. CV, including a description of relevant skills and experiences, as well as a full publication list.
3. Names, e-mail addresses, and telephone numbers for 3 referees. State their professional relation to you (e.g., PhD supervisor). Please do not include references in your application.
Starting date: as soon as possible or as otherwise agreed
Informal inquiries and applications should be sent to Martha Schattenhofer, martha.schattenhofer@icm.uu.se, with subject header "Postdoc in Molecular Biophysics".
You will join our efforts, in the framework of an ERC Advanced Grant, to develop a new multiplexed method for the real-time visualization of the complex dynamics with which nucleic acid-interacting proteins interact with DNA or RNA molecules, as a function of their nucleotide sequence. This method enables a comprehensive profiling of the sequence dependence in fundamental genome-interacting processes.
We offer you to become part of a dynamic group and a stimulating multidisciplinary environment where you will closely interact with experts in biophysics, microscopy, biochemistry, and molecular biology.
Required qualifications
A PhD in biochemistry, biophysics, physics, bioinformatics, or another relevant discipline is required. To qualify for the fellowship stipend, you must have obtained your PhD no earlier than 6 years ago. Furthermore, you should have experience with next-generation sequencing, bioinformatics, and programming. Prior experience with machine learning-based data analysis is advantageous. You should be self-motivated, creative, and have an interest in basic research and method development. As the project requires collaboration with other researchers, you should have good social skills and an excellent ability to communicate in English.
The application should be written in English and include:
1. Short letter of motivation with a short description of your research interests, and why you feel you are a good match for the project.
2. CV, including a description of relevant skills and experiences, as well as a full publication list.
3. Names, e-mail addresses, and telephone numbers for 3 referees. State their professional relation to you (e.g., PhD supervisor). Please do not include references in your application.
Starting date: as soon as possible or as otherwise agreed
Informal inquiries and applications should be sent to Martha Schattenhofer, martha.schattenhofer@icm.uu.se, with subject header "Postdoc in Molecular Biophysics".
